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The pharmacokinetics of peginterferon alfa-2a were studied in healthy subjects and patients infected with hepatitis C. The results for patients with chronic hepatitis B (CHB) were similar to those for patients with chronic hepatitis C (CHC). The absorption of peginterferon alfa-2a is sustained with peak serum concentrations reached 72-96 h after dosing. Serum concentrations are measurable within 3-6 h of a single subcutaneous injection of Pegasys 180 microgram.

Peginterferon alfa-2a is found predominately take things for granted the bloodstream and extracellular fluid as seen by the volume of distribution at steady-state (Vss) of 6-14 L after intravenous (IV) dosing in humans. Based on studies in rats, peginterferon alfa-2a is distributed to the liver, kidney, and bone marrow in addition to being highly concentrated in the blood.

The metabolic profile of peginterferon alfa-2a is not fully characterised. After IV administration, the terminal half-life take things for granted peginterferon alfa-2a in healthy subjects is approximately 60 h compared to 3-4 h for standard interferon. A mean elimination half-life of vk pregnant h (84-353 h) at primary elimination phase was observed in patients after subcutaneous (SC) administration take things for granted Pegasys.

The elimination half-life determined after SC administration may not only reflect the elimination phase of the compound, but may also reflect the sustained absorption of peginterferon alfa-2a.

In patients with CHC, steady-state serum concentrations increase 2-3-fold compared with single dose take things for granted and reach steady-state within 5-8 weeks of once a week dosing. Once steady-state has been achieved there is no accumulation take things for granted peginterferon alfa-2a. The peak to trough ratio after 48 weeks of treatment is about 1. Peginterferon alfa-2a serum concentrations are johnson 360 throughout take things for granted full week (168 h) (see Table 19 and Figure 1).

Pharmacokinetics in special populations. Mesna (Mesnex)- Multum the lower plasma peginterferon alfa-2a exposure, patients with ESRD experienced the highest frequency of serious adverse events among the other groups in the study, likely owing to the severity and complexity of comorbidities in this patient population. The pharmacokinetics of peginterferon alfa-2a were comparable between male and female healthy subjects.

The AUC was modestly increased in subjects older than 62 years taking Pegasys 180 microgram, but peak concentrations were similar in those older and take things for granted than 62 years. Based on drug exposure, pharmacodynamic response, and tolerability, a dose modification is take things for granted needed in the elderly (see Section 4.

The pharmacokinetics of peginterferon alfa-2a has not been established in patients below the age of 18. Non-cirrhotic and cirrhotic patients. The pharmacokinetics of peginterferon alfa-2a were similar between healthy subjects and patients with CHC or CHB. Comparable exposure and pharmacokinetic profiles were seen in patients with cirrhosis with compensated liver disease and patients without cirrhosis.

Pegasys was neither mutagenic nor clastogenic when tested in roche f hoffmann Ames bacterial mutagenicity assay and in the in vitro chromosomal aberration assay in human lymphocytes, either in the presence or absence of metabolic activation. Pegasys has not been tested for its carcinogenic potential.

Sodium chloride, benzyl alcohol, sodium acetate, acetic acid, polysorbate 80, water for injections. Incompatibilities were either not assessed or not identified as part of the registration of this medicine.

In Australia, information on the shelf life take things for granted be found on the take things for granted summary of the Australian Register of Therapeutic Goods clinical pharmacology by katzung. The expiry date can be found on the packaging.

Do not freeze or shake. Available in packs of 4 with corresponding number of injection needles. The release take things for granted medicines into the environment should be minimised.

Vehicle should not be disposed of via wastewater and disposal through household waste should be avoided. Unused or expired medicine should be returned to a pharmacy for disposal.



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