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Reply Dan Wyatt 22 days ago Reply to NotKMG Reply Gemma 23 days ago Reply to KMG HIGHLY doubtful… stop spreading bs to suck in the rest of the fools falling for it. Reply Gemma 23 days ago Reply to KMG I HIGHLY doubt it, unless your just raided your local FEED STORE.

Reply Chris 19 days ago Reply to Gemma Not True Ivermectin has is in pill form for humans and has been given to humans for decades. Reply Isme 14 days ago Reply to Gemma Ivermectin has been in use medically (human use) since 1981. Reply C Neal 1 month ago I tested the theory that oil keeps engines running. Reply SJH 1 month ago Reply to C Neal Reply Scott Miller 1 month ago Thank you again John for taking the time to get this information out to the public.

Reply Jack Burton 1 month ago Reply to Scott Miller The fact that someone can equate American hospitals in 2021 to Aushwitz with absolutely no argument says a lot about the community here at CCT. Reply NewsView 27 days ago Reply to Jack Burton 600K Americans died because COVID-19 positive seniors in at least four states were sent into the nursing homes - already known for being a dangerous place to be during a flu season, let alone a pandemic.

Welcome to the alpha test. Have a little common sense people Reply John Ley 22 days ago Reply to Gemma Gemma - Over 4 BILLION doses of ivermectin have been administered worldwide for humans.

Reply Michelle McDermott 16 days ago Reply to Gemma Reply Michelle McDermott 16 days ago Reply to Scott Miller Reply Anne Humphrey 1 month ago It is useful to understand that the alphabet agencies concerned with health are all captured by stakeholders in power, and not the general population.

Reply Ron Chang 18 days ago Reply to Gemma I love reading your answers, Gemma. Reply John Ley 8 days ago Reply to Ron Chang Reply Lourdes Thiruvalluvan 1 month ago I need more details on this kindly update me refer below e-mail.

The clues are more than just a warning on the wall Reply John Ley 22 days ago Reply to Gemma Gemma - Over 4 BILLION doses of ivermectin have been administered worldwide for humans. Reply Shay 3 days ago Reply to Gemma more lies Gemma ivermectin has been used on humans for more than 40 years worldwide billions of doses have been given ……The medication receive the Nobel peace prize for use in humans…….

Reply Charlaine Andrulot 1 month ago I think anyone who takes Ivermecctin is not doing the right thing. Reply John Ley 22 days ago Reply to Gemma Gemma - Over 4 BILLION doses of ivermectin have been administered worldwide for humans. Reply Ralph Gorton 20 days ago Reply to John Ley All I can say is Ivermectin worked for me to lessen Covid and protected my wife and adult son from getting seriously sick from the Covid virus.

The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents.

The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor. Since its inception it has garnered a growing share of the publishing market.

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. Over-the-counter use of ivermectin amongst other drugs as SARS-CoV-2 treatment has been increasingly common, despite the lack of evidence on its clinical efficacy. Analyses were performed between December 2020 and February 2021. Mean age was 39 years, and disease severity was similar across groups.

Although there was no evidence for differential disease severity upon ivermectin use for treatment of COVID-19 it was associated with more gastro-intestinal side-effects and impairment of anti-SARS-CoV2 antibodies production, in a dose dependent manner. This potentially impacts the effectiveness of immune response and the risk of reinfection and warrants additional studies for clarifying the mechanisms and consequences of such immunomodulatory effects.

Ivermectin is a medication of the avermectin family of compounds that is FDA-approved to treat parasite infections. Ivermectin has a controversial immunomodulatory effect in animal models, either increasing antibody production and white-blood-cell count or decreasing antibody levels in a dose dependent response. Impaired production of antibodies against COVID-19 can affect disease severity, and likelihood of reinfection. In this cross-sectional study we included HCW diagnosed with COVID-19 from May to July 2020 at Professor Edgard Santos University Hospital, in Salvador-Brazil.

After signing the informed consent form, participants donated 10 ml of blood to perform laboratory tests and filled out a questionnaire on demographics, clinical characteristics, medications and ivermectin dosages used during disease. Each dose corresponds to one 6 mg pill of ivermectin.

Samples were screened using a commercially available in vitro immunoassay (2019-nCoV IgG kit, SNIBE diagnostics, Shenzhen, China) to detect SARS-CoV-2-specific immunoglobulins against full-length spike and nucleocapsid proteins. A result greater than or equal to 1. Next, a cPass Neutralization Antibody Detection kit (Genscript, Leiden, the Netherlands) was used to detect circulating neutralizing antibodies against SARS-CoV-2 that block the interaction between the receptor binding domain (RBD) of the viral spike glycoprotein with the ACE2 cell surface receptor.

Detection of IgG antibodies against SARS-CoV-2 was performed in the microplates used to culture the PBMCs. A total of 45 HCW were evaluated. Mean time between COVID-19 diagnosis and laboratory testing was similar for IVIAP positive (110. The most used medications during acute disease were ivermectin, azithromycin, and oral corticosteroids.

Ivermectin was used by 19 HCW (8 used a single dose, 11 used multiple doses). There was no significant difference in disease severity for HCW who used ivermectin compared to those who did not. However, abdominal pain, diarrhea, and taste perversion were more frequent in HCW that used multiple doses of ivermectin (Table 1). Clinical and demographic characteristics of health care workers diagnosed with COVID-19, by ivermectin use.

In vitro cytokines production according to the ivermectin dose used by patients. There was no difference in cytokines production across groups. We showed that self-prescribed, multiple doses ivermectin use was significantly associated with lower frequency and levels of neutralizing antibodies against SARS-CoV-2.

In addition, PBMCs of most individuals who used multiple doses of ivermectin, failed to produce SARS-CoV-2 IgG antibodies when exposed to the recombinant protein S1 in a dose-dependent fashion. Ivermectin is a macrocyclic lactone that has direct action on PAK-1, interfering in phosphorylation events, essential for a large number of cellular processes.

High doses of ivermectin could induce such effects and interfere with antigen recognition and immune memory formation. The lack of evaluation of specific cellular population involved in immune response to SARS-CoV-2, and the relatively small sample size limit the reach of our conclusions. Nevertheless, our results strongly suggest that ivermectin use can interfere in the specific immune response to SARS-CoV-2 infection, affecting memory cells and the production of antibodies against that virus.

Further studies are needed to understand how this effect is promoted by ivermectin use, and what are the consequences for post-infection immunity. The study was not associated with any research grant or other funding support. We would like to express our deepest thanks to the HCW at Professor Edgard Santos University Hospital for their participation, that made this study possible.

AbstractBackgroundOver-the-counter use of ivermectin amongst other drugs as SARS-CoV-2 treatment has been increasingly common, despite the lack of evidence on its clinical efficacy. ConclusionsAlthough there was no evidence for differential disease severity upon ivermectin use for treatment of COVID-19 it was associated with more gastro-intestinal side-effects and impairment of anti-SARS-CoV2 antibodies production, in a dose dependent manner.

IntroductionIvermectin is a medication of the avermectin family of compounds that is FDA-approved to treat parasite infections. MethodsIn this cross-sectional study we included HCW diagnosed with COVID-19 from May to July 2020 at Professor Edgard Santos University Hospital, in Salvador-Brazil. ResultsA total of 45 HCW were evaluated. AcknowledgmentsWe would like to express our deepest thanks to the HCW at Professor Edgard Santos University Hospital for their participation, that made this study possible.

Influence of ivermectin on cellular and humoral immune responses of lambs. Vet Immunol Immunopathol, 44 (1995), pp. Effect of ivermectin on the cellular and humoral immune responses of rabbits.